Benzimidazole or benzoxazole derivatives for the prevention and treatment of central nervous system diseases, diabetes and its complications

摘要

The present invention provides for the prevention and treatment of central nervous system (CNS) diseases, diabetes, and complications thereof, comprising benzimidazole or benzoxazole derivatives having the structure of Formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient A pharmaceutical composition is provided. In the pharmaceutical composition of the present invention, the benzimidazole or benzoxazole derivative used as an active ingredient has an activation mechanism of Nrf2 through the Keap1-Nrf2-ARE pathway and activation of a glutamate transporter such as GLT-1/EAAT, GLAST, etc. By inhibiting oxidative damage in the central nervous system and pancreas through the pathway and inducing the production of antioxidants such as glutathione, the therapeutic effect of central nervous system diseases, diabetes and its complications can be maximized.