MESOTHELINE-TARGETED CANCER VACCINES AND THEIR APPLICATION

摘要

FIELD: biotechnology.;SUBSTANCE: invention relates to biotechnology. The present invention discloses nucleic acid molecules containing one or more nucleic acid sequences encoding a modified consensus mesothelin antigen. Described are vectors, compositions and vaccines containing one or more nucleic acid sequences encoding a modified consensus mesothelin antigen. Methods of treating a subject with a mesothelin-expressing tumor and methods of preventing a mesothelin-expressing tumor are disclosed. A modified consensus mesothelin antigen is disclosed.;EFFECT: invention makes it possible to obtain safe and effective vaccines in this field, which can be applied to mesothelin-expressing tumors, thus providing treatment and ensuring the survival of individuals affected by these types of cancer.;22 cl, 22 dwg, 17 tbl, 7 ex