Allogeneic hematopoietic stem cell transplantation method

摘要

Described herein are compositions and methods useful for the treatment of depletion of CD117+ or CD45+ cells and, inter alia, various hematopoietic diseases, metabolic disorders, cancer, and autoimmune diseases. The compositions and methods described herein can be used to treat a disorder, for example, by depleting a population of CD117+ or CD45+ cancer cells or autoimmune cells. The compositions and methods described herein may also be used to improve engraftment of allogeneic hematopoietic stem cell transplants by preparing patients for allogeneic hematopoietic stem cell transplantation therapy and selectively depleting endogenous hematopoietic stem cells prior to transplantation procedures. can