METHOD FOR PRODUCING A SPIROOXINDOLE DERIVATIVE

摘要

The present invention provides a compound having a spirooxyindole skeleton, for example, a compound having a spirooxyindole skeleton and an antitumor activity that inhibits the interaction between Mdm2 protein and p53 protein, or an intermediate thereof, efficiently using an asymmetric catalyst To provide a method for manufacturing and providing. A compound having an optically active tricyclic dyspiroindole skeleton is efficiently obtained by carrying out a catalytic asymmetric 1,3-dipole cycloaddition reaction using an asymmetric ligand and a Lewis acid using ketimine as a reaction substrate.