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18F labeled BODIPY dye and its derivatives for PET imaging of heart perfusion and others
18F labeled BODIPY dye and its derivatives for PET imaging of heart perfusion and others
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机译:18F标记的Bodipy染料及其用于心脏灌注和其他人的宠物成像的衍生物
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摘要
This invention provides a class of dual mode imaging tracer capable of acting both as a fluorescent imaging tracer and a positron emission tomography imaging tracer. Tracers in accordance with this invention generally have a fluorescent core with a boron-fluoride element embedded therein. Exemplary embodiments of the tracer include 18F-labeled BODIPY compounds and derivative thereof. Also provided are tracer kits containing a sterile formulation of a BODIPY dye either in a radio-labeled or pre-labeled state, and methods for imaging heart perfusion using the 18F-labeled dual mode tracers.
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