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A PROCESS FOR PREPARATION OF IMATINIB BY USING VILSMEIER REAGENT
A PROCESS FOR PREPARATION OF IMATINIB BY USING VILSMEIER REAGENT
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机译:使用Vilsmeier试剂制备伊马替尼的方法
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摘要
The present invention relates to a process of preparation of Imatinib, wherein said process comprises one or more steps of converting benzoic acid intermediate (formula 8) into Imatinib in presence of Vilsmeier reagent preferably under basic condition. Vilsmeier reagent in the present invention is prepared by reaction of chlorinating agent and catalyst. In a preferred embodiment Chlorinating agent is thionyl chloride and catalyst is dimethyl formamide.
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