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TARGETING TRANSFER RNA FOR THE SUPPRESSION OF NONSENSE MUTATIONS IN MESSENGER RNA
TARGETING TRANSFER RNA FOR THE SUPPRESSION OF NONSENSE MUTATIONS IN MESSENGER RNA
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机译:靶向转移RNA用于抑制信使RNA中的无意义突变
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摘要
The disclosure provides for a targeting transfer RNA (ttRNA) that that suppresses nonsense mutations in messenger RNA, that comprises an anticodon sequence that binds to a stop codon and a variable loop sequence that comprises an RNA aptamer that has strong binding affinity to an RNA binding protein; and methods of use thereof.
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