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CANCER LESION TISSUE EVALUATION FOR OPTIMIZING EFFECT OF BORON NEUTRON CAPTURE THERAPY

机译:癌症病变组织评价优化硼中子捕获疗法的影响

摘要

The present invention to a method, a kit, etc., for predicting the response BNCT using a BSH-related medicine-containing boron preparation and a BPA-containing boron preparation, the method and kit being characterized by examining the expression of CD44, a translation-related factor and/or LAT1 in cancer cells of a sample. When the expression of the CD44 or translation-related factor in the cancer cells of the sample is high, it can be predicted that the BNCT using the BSSH-related medicine-containing boron preparation is likely to be responsive. When the expression of the LAT1 in the cancer cells of the sample is high, it can be predicted that the BNCT using the BPA-containing boron preparation is likely to be responsive.
机译:本发明通过使用BSH相关的含硼制剂和含BPA的硼制剂来预测响应BNCT的方法,试剂盒等,通过检查CD44,a的表达,所述方法和试剂盒在样品的癌细胞中的翻译相关因子和/或Lat1。当样品的癌细胞中CD44或平移相关因子的表达很高时,可以预测使用使用BSSH相关的含有BSSH的硼制剂的BNCT可能是响应的。当样品的癌细胞中LAT1的表达高时,可以预测使用含BPA的硼制剂的BNCT可能是响应的。

著录项

  • 公开/公告号US2021215713A1

    专利类型

  • 公开/公告日2021-07-15

    原文格式PDF

  • 申请/专利权人 3-D MATRIX LTD.;

    申请/专利号US201916970199

  • 发明设计人 HIDEKI MATSUI;ATSUSHI FUJIMURA;

    申请日2019-02-08

  • 分类号G01N33/68;A61K33/22;G01N33/50;

  • 国家 US

  • 入库时间 2022-08-24 19:56:56

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