Systems and methods for managing interrupts generated by network interface controllers. An example method may comprise: responsive to determining that a memory pressure metric in a computer system does not exceed a threshold value, disabling interrupts that signal completion of a packet transmission by a network interface controller; transmitting a plurality of data packets by the network interface controller; and responsive to detecting that the memory pressure metric exceeds the threshold value, releasing a memory buffer allocated to a data packet of the plurality of data packets.
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