AN IMPROVED PROCESS FOR THE PREPARATION OF 4-({(1 R)-2-5-(2-FLUORO-3METHOXYPHENYL)-3-{2-FLUORO-6-(TRIFLUORO METHYL) PHENYLMETHYL}-4-METHYL-2,6-DIOXO-3,6DIHYDROPYRIMIDIN-1(2 H)-YL-1-PHENYLETHYL}AMINO)BUTANOIC ACID OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS

摘要

The present invention relates to an improved process for the preparation of 4- ({(1R) -2- [5- (2-fluoro- 3­ methoxy phenyl) – 3 - {[ 2-fluoro- 6-(trifluoro methyl) phenyl] methyl} -4-methyl- 2,6-dioxo- 3,6­dihydropyrimidin-1(2H)-yl]-1-phenylethyl}amino) butanoic acid of formula (I) or its pharmaceutically acceptable salts. The compound of formula (I) is represented by the following structural formula.