Template-based Hippocampus Subfield Atrophy Analysis in Alzheimer's Disease and Normal Aging

摘要

The present invention relates to a template-based hippocampal subfield atrophy analysis method in Alzheimer's disease and normal aging, in which a 3D hippocampal model is extracted by performing image preprocessing through hippocampal region of interest segmentation and volume rendering on T1-MR images, , create a 3D point cloud for the 3D hippocampus model, create and register a 3D hippocampus point cloud model, create a 3D medial axis model image through the medial axis calculation step of the registered 3D hippocampus point cloud model, and calculate the 3D radial distance Effect of hippocampal subfield atrophy in Alzheimer's disease (AD) by calculating a 3D radial distance model and performing radial distance color mapping, followed by surface-based shape analysis and 3D voxel-based morphometry in the hippocampal subfield is made to analyze