A method for characterizing a region of interest including adipose tissue using medical imaging data of a subject is disclosed. The method includes calculating a radiomic signature value of the region of interest using the medical image data. Also disclosed is a method of deriving a radiomic signature indicative of adipose tissue dysfunction. The method includes acquiring a radiomic data set and constructing a radiomic signature of a region of interest comprising adipose tissue using the radiomic data set. Also disclosed is a system for performing the method described above.
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