IN VIVO DEGRADABLE UPCONVERSION NANOMATERIAL, AND PREPARATION METHOD THEREFOR AND USE THEREOF

摘要

Disclosed are an in vivo degradable upconversion nanomaterial, and a preparation method therefor and a use thereof. The material is a rare earth-doped zirconium/hafnium-based alkali metal fluoride, wherein the fluoride serves as a matrix material and has a general formula of M_xT_yF_{x + 4y}, and the doped nanomaterial has a structural formula of M_xT_yF_{x + 4y}:z%Ln, where M is one or more of Li, Na and K; T is Zr and/or Hf; Ln is one or more of Yb, Er, Tm, Ho, Gd, Eu, Tb, Sm, Dy, Ce and Nd; and 1 ≤ x ≤ 7, 1 ≤ y ≤ 6, and 0 ≤ z ≤ 50. The material can be rapidly hydrolyzed and eliminated in vivo, is not prone to aggregation in large quantities in vivo, and has low cytotoxicity and biotoxicity, exhibiting good biosafety. Moreover, the decomposition of the material in a weakly acidic tumor environment will be inhibited to a certain degree, which slows the progression of hydrolysis thereof. Further, the residence time of the material in a weakly acidic tumor environment is longer than that in other environments in vivo, which permits specific fluorescent labeling of a tumor.