A unilaterally driven closed-loop artificial pancreas, comprising: a detection module (100), an infusion module (102) and a program module (101). The infusion module (102) includes a reservoir (110), a piston (120), a screw (130), a driving unit, a driving wheel (140) provided with wheel teeth (141), at least one linear actuator (180) and at least one reset unit (170). The driving unit includes at least one rotating shaft (160) and at least one driving member (150). The driving member (150) includes a driving end (151). The driving member (150) rotates around the rotating shaft (160). The linear actuator (180) and the reset unit (170) respectively connect to the driving member (150). The program module (101) is connected to the detection module (100) and the infusion module (102) respectively, imported the total daily dose algorithm and the current insulin infusion algorithm. The driving power can be controlled, and it can accurately calculate the TDD value and the current insulin infusion dose.
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