CD 8 α How to use them in the regulation of mutants and T-cell receptor variants and responses of immune cells

摘要

Novel costimulatory fusion proteins and DNA sequences are disclosed that enhance T cell responses to weakly immunogenic and / or low expressed antigens and confer resistance to MDSC mediated suppression to T cells. The fusion protein comprises a portion of a T cell receptor or other signaling molecule linked to a specific region of CD4, CD8α or MyD88. These fusion proteins and their sequence variants improve T cell activation and responsiveness. Use of these molecules in host cells as a means to enhance and costimulate the response of immune cells, including cytotoxic CD8 + T cells, and use of these cells to treat cancer, infectious pathogens and other diseases Is also disclosed.