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THERAPEUTIC PROTEIN SELECTION IN SIMULATED IN VIVO CONDITIONS
THERAPEUTIC PROTEIN SELECTION IN SIMULATED IN VIVO CONDITIONS
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机译:在体内条件下模拟的治疗蛋白选择
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摘要
A method of determining the effect of non-specific interactions in simulated in vivo conditions is presently disclosed. The method includes (a) contacting a solution comprising a biologically relevant molecular crowding agent and a target molecule with a biosensor, wherein the surface of the biosensor comprises a capture molecule that specifically binds the target molecule; (b) allowing the target molecule to bind to the capture molecule; and (c) determining an amount of the target molecule bound to capture molecule using biolayer interferometry.
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