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MICRONEEDLE DELIVERY DEVICE WITH DETACHABLE HYBRID MICRONEEDLE DEPOTS FOR LOCALIZED DELIVERY OF CELLS
MICRONEEDLE DELIVERY DEVICE WITH DETACHABLE HYBRID MICRONEEDLE DEPOTS FOR LOCALIZED DELIVERY OF CELLS
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机译:具有可拆卸混合微针码的微针递送装置,用于局部递送细胞
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摘要
A delivery device or patch is disclosed that includes a detachable hybrid microneedle depot (d-HMND) for cell delivery. The system includes, in one embodiment, an array of microneedles formed from an outer PLGA shell and an internal gelatin methacryloyl (GelMA)-mesenchymal stem cells (MSC) mixture (GMM). The array of microneedles project from a base substrate layer that may be flexible. The therapeutic device may be applied to a tissue site of interest and the base substrate layer is removed leaving the hybrid microneedles in the tissue at the site of application to deliver MSCs. Other stem/therapeutic cells may also be delivered with the hybrid microneedles.
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