METHODS FOR IDENTIFYING VIRAL INFECTIONS AND FOR ANALYZING EXOSOMES IN LIQUID SAMPLES BY RAMAN SPECTROSCOPY

摘要

The present invention relates to an in vitro method for analysing liquid samples as to the presence, identity and properties of a virus comprising: a) analyzing said liquid samples for a virus spectroscopically by means of spontaneous Raman spectroscopy; and b) comparing the spectroscopic data to a database and identifying said virus. The present invention further relates to an in vitro method for analyzing exosomes in a liquid sample of a subject comprising: a) isolating exosomes from the liquid sample; b) analyzing said exosomes spectroscopically by means of spontaneous Raman spectroscopy; and c) obtaining a Raman spectrum for said exosomes. The present invention also refers to a device for analysing a liquid sample as to the presence, identity and properties of viruses; and to a device for analyzing exosomes in a liquid sample. Also envisaged are a method for monitoring a viral infection in a cell or group of cells and a method of monitoring the antiviral treatment effect in a virus infected cell or group of cells, as well as a system comprising said device and a module comprising a database comprising reference values of Raman spectra.