Novel genes for regulating the virulence of Cryptococcus neoformans and their use

摘要

The present invention relates to novel genes for regulating the toxicity of Cryptococcus neoformans strains and uses thereof. According to the present invention, by detecting the expression level of a novel transcription factor of a Cryptococcus neoformans strain, it is possible to effectively search for a candidate substance having an antibacterial effect or a meningitis treatment effect. In addition, a screening method for a candidate substance that may have a synergistic effect when administered in combination with an existing antibacterial agent or a therapeutic agent for meningitis is provided, and a pharmaceutical composition having an antibacterial or meningitis treatment effect by increasing or inhibiting the expression of a novel transcription factor can provide In the present invention, a large-scale toxicity analysis using an insect model and an animal model was performed to identify a number of transcription factors related to the pathogenicity of Cryptococcus neoformans, and the complex correlation between the in vitro and in vivo phenotypic characteristics of the homogeneous pathogen was investigated. identified.