LATS1 Gene Mutation Marker Based Diagnosis of Amyotrophic Lateral Sclerosis

摘要

The present invention relates to a diagnostic method for amyotrophic lateral sclerosis based on LATS1 gene mutation. The present invention provides an accurate and efficient marker-based diagnostic method for diagnosing amyotrophic lateral sclerosis that lacks effective molecular diagnostic markers. The marker of the present invention can diagnose amyotrophic lateral sclerosis even when a previously reported marker is not found, and suggests a new diagnostic method for amyotrophic lateral sclerosis. The diagnostic method, marker, and use thereof of the present invention are useful in the diagnosis, prediction, treatment and prevention of amyotrophic lateral sclerosis. Furthermore, the LATS1 gene of the present invention can be used to study the onset mechanism of amyotrophic lateral sclerosis and develop a drug for treatment.