CO-CRYSTALS OF TRANSMEMBRANE CONDUCTION REGULATOR MODULATORS IN CYSTIC FIBROSIS

摘要

FIELD: crystal chemistry.;SUBSTANCE: invention relates to co-crystals containing N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), with Compound 1 being represented by the following structural formula:; ;and only one triglyceride, with the triglyceride being selected from glyceryltrioleate, glyceryltrioctanoate and glyceryltrilinoleate, as well as to the methods for their obtaining and methods for treating cystic fibrosis using them. ;EFFECT: treatment of cystic fibrosis with their help.;11 cl, 37 dwg