GLIFLOZIN SYNTHESIS METHOD USING METHANESULFONYLATED INTERMEDIATES IN A CONTINUOUS FLOW CHEMISTRY PROCESS

摘要

Step 1 The present invention relates to a synthetic method in binary ripple article, by reacting the stream comprising the initial reactants and the stream, and n- butyl lithium (n-Butyllithium), including lactones for producing a first product; and a second step of reacting a stream comprising the first product and a stream comprising a mesylation reagent to produce a second product; and a third step of reacting the stream comprising the second product and the stream comprising the acid to produce a third product.