首页>
外国专利>
Development of dual whole cell-based vaccine against pancreatic cancer
Development of dual whole cell-based vaccine against pancreatic cancer
展开▼
机译:抗胰腺癌双全细胞疫苗的发展
展开▼
页面导航
摘要
著录项
相似文献
摘要
Disclosed herein is a different and novel approach to cancer vaccines using a subject's own dendritic cells (DCs) and macrophages (Mphs) in combination to present cancer antigens to the immune system. Further disclosed are methods of producing monocyte-derived autologous DCs and Mphs loaded ex vivo with particular whole irradiated cancer cells which generates optimally activated immunostimulatory antigen-presenting cells (APCs) as a superior method for stimulating robust and long-lasting immunity to a particular cancer in vivo as compared with more traditional vaccination methods. Compositions, methods of use and methods for preparation of these DCs and Mphs with cancer cells are also disclosed herein.
展开▼