Methods and systems for performing security sanitization of Universal Serial Bus (USB) devices are provided. According to one embodiment, existence of a Universal Serial Bus (USB) device connected to a USB port of a network security device is detected by the network security device. Responsive thereto, read and write access to a memory of the USB device is facilitated, by mounting, by the network security device, the USB device within a file system of the network security device. Multiple security scans are caused to be performed by the network security device on the USB device, including: (i) an antivirus (AV) scan to identify existence of one or more known viruses using an AV engine of the network security device and (ii) a vulnerability scan for one or more known vulnerabilities or exploits using a detection engine of the network security device.
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