NOVEL METALLO-BETA-LACTAMASE INHIBITOR CREATED IN MULTI-DRUG RESISTANT BACTERIA, AND PREPARATION METHOD THEREFOR

摘要

The present invention relates to a novel metallo-beta-lactamase (MBL) inhibitor and an antibacterial composition to be used against multi-drug resistant bacteria, containing same, and is a compound of chemical formula 1 or a derivative thereof, and, more specifically, is 3,5-dichlorophenylboronic acid, (4-(4-amino-3- chlorophenoxy)-3,5-dichlorophenyl) boronic acid and (3,5-dichloro-4-(2-hydroxyethoxy)phenyl)boronic acid. An MBL inhibitor of chemical formula 1, according to the present invention, has an inhibitory activity against a broad spectrum of MBLs. Therefore, when an MBL according to the present invention and an antibiotic having a β-lactam structure are used together in treatment, degradation of the antibiotic due to MBL produced by microorganisms is prevented so that the duration of action and range of the antibiotic can be extended, and bacteria that can acquire resistance to an antibiotic due to the presence of MBL can be killed, and thus infection by multi-drug resistant bacteria is effectively prevented and treated.