A pharmaceutical composition for treating stroke containing sildenafil and Rho-associasted kinase inhibitor

摘要

The present invention relates to a pharmaceutical composition for the treatment of stroke comprising a phosphodiesterase type 5 activity inhibitor (phosphodiesterase type 5 inhibitor) and a ROCK inhibitor (Rho-associasted kinase inhibitor), and more specifically comprising sildenafil and GSK429286A , It relates to a pharmaceutical composition for treating brain damage due to stroke. The present inventors studied to use sildenafil and a ROCK inhibitor in combination in the treatment of stroke based on clinical knowledge related to stroke treatment.As a result, when sildenafil and a ROCK inhibitor were administered in combination, when sildenafil and a ROCK inhibitor were administered alone. Compared to that, it was confirmed for the first time that the size of brain damage due to stroke is significantly reduced.The pharmaceutical composition according to the present invention will be usefully used not only for the treatment of stroke, but also for the study of various ischemic cerebrovascular diseases including ischemic stroke. Is expected.