PHARMACEUTICAL COMPOSITION COMPRISING THE EXTRACT OF BLACK SOLDIER FLY AS AN EFFECTIVE COMPONENT FOR PREVENTION OR TREATMENT OF THROMBOSIS AND HEALTH FUNCTIONAL FOOD COMPRISING THE SAME

摘要

The present invention relates to an antithrombotic composition containing an extract of Dongae et al. ( Hermetia illucens ) as an active ingredient, and in more detail, the larvae, pupa, yonggak (shell after pupa molting) and adult insect extracts as active ingredients It relates to a pharmaceutical composition for the prevention or treatment / improvement of thrombosis containing and health functional food. Dongae et al. extract as an active ingredient of the pharmaceutical composition for preventing or treating thrombosis of the present invention and a health functional food, as demonstrated through the examples of the present specification, by inhibition of enzymes related to thrombosis and inhibition of blood coagulation factors It exhibits strong antithrombotic activity and antithrombotic effect by inhibiting human platelet aggregation. At low concentrations of 0.5mg/ml or less, hemolytic activity against human red blood cells is very insignificant, excellent thermal stability, and acidic at pH 2 Since there is no loss of the effect of inhibiting blood clotting factors and enzymes related to blood clotting even in conditions and plasma, it is expected that it can be used for the prevention and treatment of thrombosis such as ischemic stroke and hemorrhagic stroke through improvement of blood circulation, and the active ingredient is an extract. It is a very useful invention in the pharmaceutical industry and the food industry because it has an excellent effect that can be prepared in a form that can be taken at any time by being processed into various forms such as powder, pill, and tablet.