Induced microbial remodeling platform for rational improvement of microbial species for agriculture

摘要

The present invention provides an induced microbial remodeling (GMR) method for rational improvement of plant-related microbes to perform plant-beneficial functions. The GMR method described in the present invention enables non-genusal gene optimization of the major regulatory networks within the microorganism to improve plant-beneficial function compared to wild-type microorganisms, but does not have the risks associated with the transformation approach (e.g., unpredictable. Missing gene function, disclosure and regulation issues, etc.). The present invention also provides remodeled microorganisms and compositions thereof. Utilizing remodeled microorganisms and their compositions, farmers can realize more productive and predictable crop harvests without nutrient degradation, leaching or toxic spills associated with traditional synthetically derived fertilizers.