CO-ADMINISTRATION OF STEROIDS AND ZOLEDRONIC ACID TO PREVENT AND TREAT OSTEOARTHRITIS

摘要

Combination therapy for treating osteoarthritis is disclosed. The combination therapy includes co-administration of steroids and zoledronic acid. Co-administration of steroids reduces the production of cytokines, and thus reduces the pro-inflammatory effect of zoledronic acid. Co-administration of zoledronic acid and steroids treats osteoarthritis and prevents the onset of osteoarthritis in patients at risk for osteoarthritis.