The present invention uses a composition for reducing biotoxicityby nanomaterials containing Hydra magnapillata Protein (HP) or a peptide extracted from Hydra, and a composition for reducing biotoxicity by a hydra protein or a peptide extracted from a hydra protein. Regarding a method of reducing toxicity, when the hydra protein of the present invention or a peptide extracted from hydra is used, nanomaterials (100 nm or less) and microparticles can be used as a material against environmental diseases that may occur due to the introduction of the organism, Since there is no secondary environmental pollution due to bioaccumulation and the use of chemicals during this process, it can be usefully used as a material that can reduce environmental diseases of ultrafine particles including nanoparticles.
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