PROBLEM TO BE SOLVED: To provide effective treatment of overweight and obesity in subjects at increased risk of adverse cardiovascular outcomes.SOLUTION: The present disclosure relates to compositions, kits, uses, systems and methods for treating overweight and obesity using naltrexone plus bupropion, preferably in combination with a comprehensive web-based and/or telephone-based weight management program, and preferably in subjects at increased risk of adverse cardiovascular outcomes.SELECTED DRAWING: None
展开▼