A NOVEL NANOTECHNOLOGIC APPROACH TO GLIOBLASTOMA TREATMENT WITH SOLID LIPID CARRIERS

摘要

The invention is to a solid lipid nanoparticle, which is a targeted drug delivery system that can cross the blood-brain barrier for use in the treatment of Glioblastoma. With the invention, solid lipid nanoparticles (SLN) containing carmustine (BCNU) and temozolomide (TMZ) are prepared and the surface of these nanoparticles is coated with polysorbate 80 to cross the blood brain barrier (BBB). The drug system is formulated for intranasal administration in order to reach the brain with a higher concentration of solid lipid nanoparticles loaded with the prepared dual drug system.