Triazole, imidazole and pyrrole condensed piperazine derivatives, and their use as modulators of mGlu5 receptors

摘要

Triazole, imidazole and pyrrole condensed piperazine derivatives, and their use as allosteric modulators of mGlu5 receptor activity, such as compounds and methods of treatment thereof are disclosed.Compound of the inventionSchizophrenia or cognitive declineNeuropathy and mental disorders associated with glutamate dysfunction such as dementia or cognitive impairmentOr other pathological conditions that may be directly or indirectly associated with glutamate dysfunctionThat is,A possible allosteric modulation (mum) of mGluR5 or a therapeutic disorder of negative antistatic modulation (NAM)May be used for treatment and / or prevention.