Humanized affinity maturation antibody and use method for fcrh5

摘要

To provide anti-FcRH5 antibodies for treating FcRH5-positive cancers, e.g., multiple myeloma.SOLUTION: An anti-FcRH5 antibody that binds to FcRH5 and CD3 comprises an anti-FcRH5 arm comprising a first binding domain comprising six HVRs: and an anti-CD3 arm comprising a second binding domain comprising other six HVRs.SELECTED DRAWING: None