Dual recognition two-photon fluorescent probe and uses thereof

摘要

The present invention relates to a tumor-specific double-recognition two-photon fluorescent probe and a method for diagnosing cancer disease using the same, and more particularly, a two-photon fluorescent probe in which D-glucosamine and β-D-galactopyranoside are bound to a double recognition site. It can be selectively absorbed by cancer cells through glucose receptors overexpressed in cancer cells, and exhibits fluorescence and color change through abnormally upregulated β-galactosidase (β-gal) hydrolytic enzyme activity in cancer cells, and the above As it is possible to diagnose cancer disease and confirm the progression stage of cancer disease through the color change rate and color intensity of the two-photon fluorescent probe, the double-recognition two-photon fluorescent probe of the present invention is accurate and effective cancer disease diagnosis information in the treatment of cancer diseases. Can provide.