Compositon comprising the 8-methoxyobliquin compound isolated from Helianthus tuberosus leaves MeOH extraction for preventing or treating immune checkpoint inhibitor

摘要

Provides a pharmaceutical composition for the treatment of anticancer drug-resistant tumors that has an immune checkpoint inhibitor effect that can be safely used without toxicity and side effects by using 8-methoxyobliquin, which is an immune checkpoint inhibitor containing chemical ingredients as the main raw material, isolated from the above-ground part of pork potato, a native domestic resource. do. The composition of the present invention contributes to the treatment of an immune checkpoint inhibitor by inhibiting the expression of anti-programmed death-ligand 1 (PD-L1), enhancing the activity of T cells, and inhibiting benign tumor activity.