A sustained release antacidal oral probiotic crystal ball structure comprising a spherical probiotic core (1), a protective layer (2) applied to the core (1), a release delay layer (3) applied to the protective layer (2), a release delay layer (3) applied bile salt-pancreatic juice-resistant layer (4), an acid-resistant layer (5) applied to the bile-salt-pancreatic juice-resistant layer (4) and an insulating layer (6) applied to the acid-resistant layer (5).
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