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INHIBITOR FOR CARBAPENEM HYDROLYSIS CLASS D BETA-LACTAMASE (CHDL) AND PREPARATION METHOD THEREOF
INHIBITOR FOR CARBAPENEM HYDROLYSIS CLASS D BETA-LACTAMASE (CHDL) AND PREPARATION METHOD THEREOF
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机译:碳烯烃水解级Dβ-内酰胺酶(CHDL)的抑制剂及其制备方法
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摘要
The present invention relates to an inhibitor for carbapenem hydrolysis class D beta-lactamase and a preparation method thereof and, more particularly, to [3-(2-phenylethoxy)phenyl]boronic acid or a pharmaceutically acceptable salt thereof for inhibiting CHDL, and a preparation method thereof. [3-(2-phenylethoxy)phenyl]boronic acid or a pharmaceutically acceptable salt thereof according to the present invention inhibits all six clinically important subgroups of CHDL and four newly emerging CHDL subgroups. Accordingly, the compound according to the present invention inhibits a wide variety of CHDLs such that when used together with beta-lactam antibiotics, the compound is effective for treatment of infections caused by bacteria that develop antibiotic resistance due to various CHDLs.
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