METHODS AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF ISCHEMIA REPERFUSION INJURY AND INFECTION

摘要

Disclosed herein are compositions for treating a subject with ischemia reperfusion injury or at risk of developing ischemia reperfusion injury, the method comprising administering to the subject an agonist of nicotinic cholinergic receptor α7nAchR. Also disclosed are methods and compositions for treating a subject with sepsis or at risk of developing an infection or sepsis, the method comprising administering to the subject an agonist of nicotinic cholinergic receptor α7nAchR. In one embodiment, the agonist of nicotinic cholinergic receptor α7nAchR is varenicline.