Mesenchymal stem cells expressing brain-derived neurotrophic factor and their uses

摘要

The present invention presents a large amount of recombinant lentivirus containing a gene encoding brain-derived neurotrophic factor protein (BDNF), mesenchymal stem cells transfected with the lentivirus, and a large amount of cell therapeutic agent expressing BDNF protein using the same. Regarding how to produce in. The mesenchymal stem cells transfected with the recombinant lentivirus of the present invention can regulate the expression time of BDNF protein, show a high cell proliferation rate and a high BDNF protein expression level, and are excellent in safety. , It can be mass-produced and is usefully used for the treatment of various neurological diseases as a stem cell therapeutic agent capable of maintaining the same effect. [Selection diagram] Fig. 5