The present invention discloses a method for chemically synthesizing Plesiomonas shigeroides O51 serotype O-antigen oligosaccharide, and belongs to the field of chemistry. The present invention uses abundantly derived D-glucose, L-fucose, D-glucosamine and the like as raw materials to produce three types of glycosylation constituent blocks, and designs a synthetic pathway consisting of 11 reaction modules. We succeeded in completing the production of the target oligosaccharide chain by optimizing the protecting group and the timing of introducing the modifying group. The oligosaccharide chain produced by the present invention has an inexpensive raw material, is easily available, has a simple production method, has excellent reproducibility, and is good in terms of development of new drugs and vaccines of Plesiomonas shigeroides. It has the potential for application. [Selection diagram] Fig. 1
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