Use of circulating microparticles to stratify the risk of spontaneous preterm birth

摘要

The present invention relates to spontaneous preterm birth proteomics biomarkers, term birth proteomics biomarkers, and methods of their use. In particular, the present invention provides tools for determining whether a pregnant subject is at high risk of preterm birth, as well as for reducing the risk of preterm birth for a pregnant subject. In certain embodiments, a highly predictable test is provided to detect spontaneous preterm birth during the first trimester of pregnancy in a non-pregnant subject, regardless of birth history, in the pregnant subject. Other highly predictable tests are provided to detect spontaneous preterm birth during the first trimester of pregnancy.