Micro-nanomaterials, products whose surfaces are covalently modified with hydrophilic substances, and manufacturing methods

摘要

The present invention provides a micro-nanomaterial, a product in which the surface is covalently modified with a hydrophilic substance, and a production method. The surface of the micro-nanomaterial contains a carboxyl group or a latent carboxyl group and is converted to an active ester. The product in which the surface is covalently modified with a hydrophilic substance modifies the hydrophilic compound and / or hydrophilic polymer containing aliphatic primary amine and / or aliphatic secondary amine to the surface active ester. As an agent, it is obtained by performing a covalent bond modification so as to form an amide bond. At the time of production, a monomer containing a carboxyl group and / or a latent carboxyl group is used to form sufficiently many carboxyl groups and / or latent carboxyl groups on the surface of the polymerizing material, which are converted to active esters, aliphatic primary amines A covalent modification layer is obtained by forming an amide bond with a suitable modifier and / or containing a secondary amine, a latent zwitterionic group, a hydrophilic linking arm and the volume. After the active ester is repeatedly formed on the surface of the covalently modified product, multi-layered covalent modification is realized by the process of forming an amide bond with the hydrophilic modifier, and the volume-appropriate hydrophilic modifier makes the micro nanomaterial surface The efficient coating of S. reduces significantly the nonspecific adsorption of the modified product to biomolecules.