ENGINEERING RED BLOOD CELLS FOR TREATING GOUT AND HYPERURICEMIA DISEASES

摘要

Provided are engineered red blood cells comprising a urate oxidase (UOX) or a functional variant thereof; a urate transporter 1 (URAT1) or a functional variant thereof; or a UOX or a functional variant thereof and a URAT1 or a functional variant thereof. Provided are the uses of the engineered red blood cells in treating hyperuricemia associated diseases.