IMMUNE RESPONSE SUPPRESSOR

摘要

The present invention addresses the problem of clarifying the immune response mechanism of IL-17-producing cells, said immune response mechanism inducing pathological conditions such as psoriasis, to thereby provide an immune response suppressor for suppressing the immune response of IL-17-producing cells, a drug for treating or preventing diseases or pathological conditions in which the immune response of IL-17-producing cells participates, a method for inducing the immune response in γδT cells, and a method for evaluating a drug (a candidate substance) and a method for producing IL-17, each method using the aforesaid method.　The present invention pertains to: an immune response suppressor for IL-17-producing cells, said immune response suppressor comprising a substance inhibiting the binding to at least one protein selected from among CD96, CD155 and CD111; a drug comprising the immune response suppressor for IL-17-producing cells; a method comprising step (A) for culturing γδT cells and/or CD4-positive T cells together with IL23, an anti-CD3 antibody capable of stimulating TCR/CD3 complex and an anti-CD96 antibody capable of stimulating CD96; and a method for evaluating a drug (a candidate substance) and a method for producing IL-17, each method using the method comprising step (A).