METHODS OF TREATING SYSTEMIC LUPUS ERYTHEMATOSUS

摘要

Provided are methods of treating Systemic Lupus Erythematosus (SLE) in subjects in need thereof. In certain embodiments, the subjects in need thereof are identified as having cytotoxic CD8+ T lymphocytes comprising a particular expression profile, and the methods comprise administering an effective amount of an agent that targets the cytotoxic CD8+ T lymphocytes. According to some embodiments, the subjects in need thereof are identified as having activated monocytes comprising a particular expression profile, and the methods comprise administering an effective amount of an agent that targets the activated monocytes. In certain embodiments, the subjects in need thereof are identified as having macrophages comprising a particular expression profile, and the methods comprise administering an effective amount of an agent that targets the macrophages. Also provided are methods that find use, e.g., in identifying the subjects in need thereof.