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MULTIPLEXED DETECTION WITH ISOTOPE-CODED REPORTERS
MULTIPLEXED DETECTION WITH ISOTOPE-CODED REPORTERS
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机译:使用同位素编码的记者进行多路复用检测
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摘要
Some aspects of this invention provide reagents and methods for the sensitive, quantitative and simultaneous detection of target analytes in complex biological samples by liquid chromatography tandem mass spectrometry (LC MS/MS). Some aspects of this invention provide affinity reagents encoded with mass reporters for the sensitive and quantitative translation of an analyte of interest into a mass tag. The reagents and methods provided herein have general utility in analyte detection and encoding, for example, in biomolecular profiling, molecular diagnostics, and biochemical encoding.
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机译:本发明的一些方面提供了通过液相色谱串联质谱法(LC MS / MS)的复杂生物样品中敏感,定量和同时检测敏感,定量和同时检测靶分析的试剂和方法。本发明的一些方面提供了与批量报告者编码的亲和试剂,用于对肿块标签的敏感和定量平移的敏感和定量平移。本文提供的试剂和方法具有分析物检测和编码的一般效用,例如,在生物分子分析,分子诊断和生物化学编码中。
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