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Bacterially derived, intact minicells for delivery of therapeutic agents to brain tumors
Bacterially derived, intact minicells for delivery of therapeutic agents to brain tumors
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机译:细菌衍生的,完整的迷你蛋白,用于将治疗剂递送至脑肿瘤
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摘要
Systemic administration of intact, bacterially derived minicells results in rapid accumulation of the minicells in the microenvironment of a brain tumor, in therapeutically significant concentrations, without requiring endothelial endocytosis/transcytosis across the blood brain barrier or any other mechanism by which, pursuant to conventional approaches, nanoparticles have entered into that microenvironment. Accordingly, a wide variety of brain tumors, both primary and metastatic, can be treated by administering systemically a therapeutically effective amount of a composition comprised of a plurality of such minicells, each minicell being a vehicle for an active agent against the tumor, such as a radionuclide, a functional nucleic acid or a plasmid encoding one, or a chemotherapeutic agent.
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