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Sequencing data analysis method, device and computer-readable medium for microsatellite instability

机译:测序数据分析方法,设备和计算机可读介质,用于微卫星不稳定性

摘要

A sequencing data analysis method, a device and a computer-readable medium for microsatellite instability. The present invention can use NGS sequencing results to determine whether the microsatellite instability is present. The sequencing data analysis method can significantly improve detection sensitivity without reducing specificity, and can quickly and automatically evaluate a stable or unstable status of each MSI locus with high throughput, high sensitivity, and high specificity. By combining the statuses for all MSI loci in each sample, the samples can be comprehensively evaluated as MSS, MSI-L, or MSI-H.
机译:用于微卫星不稳定性的测序数据分析方法,设备和计算机可读介质。本发明可以使用NGS测序结果来确定是否存在微卫星不稳定性。测序数据分析方法可以显着提高检测灵敏度而不会降低特异性,并且可以快速地自动评估每个MSI基因座的稳定或不稳定状态,具有高吞吐量,高灵敏度和高特异性。通过将所有MSI基因位的状态组合在每个样本中,可以将样本综合地评估为MSS,MSI-L或MSI-H。

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