BASE EDITOR-MEDIATED CD33 REDUCTION TO SELECTIVELY PROTECT THERAPEUTIC CELLS

摘要

Systems and methods to selectively protect therapeutic cells by reducing CD33 expression in the therapeutic cells using base editors and targeting non-therapeutic cells with an anti-CD33 therapy are described. The selective protection results in the enrichment of the therapeutic cells while simultaneously targeting any diseased, malignant and/or non-therapeutic CD33 expressing cells within a subject.